منابع مشابه
Purification and activation of Clostridium botulinum type E toxin.
Type E strains of Clostridium botulinum tend to produce toxin of relatively low mouse killing power (administered intraperitoneally) in relation to its high lethality per os for man. The explanation of this peculiarity seems to lie in the phenomenon of "activation," whereby type E toxin, when exposed at an appropriate pH in vitro to certain bacterial enzymes (Dolman, 1953, 1957a; Sakaguchi and ...
متن کاملMechanism of Tryptic Activation of Clostridium Botulinum Type E Toxin.
Gerwing, Julia (University of British Columbia, Vancouver, B.C., Canada), Claude E. Dolman, and Arthur Ko. Mechanism of tryptic activation of Clostridium botulinum type E toxin. J. Bacteriol. 89:1176-1179. 1965.-The toxic peptide of trypsin activated Clostridium botulinum type E toxin was purified by chromatography through columns packed with Sephadex G-75 and G-50. The molecular weight of the ...
متن کاملActivation phenomenon of Clostridium botulinum type E toxin.
Gerwing, Julia (The University of British Columbia, Vancouver, Canada), Claude E. Dolman, and David A. Arnott. Activation phenomenon of Clostridium botulinum type E toxin. J. Bacteriol. 84:302-306. 1962-Highly purified preparations of both nonactivated and trypsin-activated type E botulinus toxins have been analyzed in an ultracentrifuge. Untreated botulinus type E toxin was found to have a sed...
متن کاملSignificance of 12S toxin of Clostridium botulinum type E.
The pathogenesis of type E botulism is discussed as an aspect of the physicochemical and biological properties of 12S toxins (prototoxin and trypsin-activated 12S toxin) and the Ealpha and Ebeta components of each 12S toxin. A molecular weight of 350,000 was determined for each 12S toxin and 150,000 for Ealpha and Ebeta. Owing to the structure comprising the subunits Ealpha and Ebeta, 12S toxin...
متن کاملActivation of Clostridium botulinum type E toxin by trypsin.
Since 1936, when the type E strain of Clostridium botulinum was first established as a result of the work of Gunnison et al. (1936), 17 outbreaks of Type E botulism have been reported, involving 69 persons, of whom 21 died (Dolman and Chang, 1953; Dolman et al., 1955). Although the large proportion of fatalities suggests that this organism is highly toxigenic, published reports indicate that in...
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ژورنال
عنوان ژورنال: Nippon Saikingaku Zasshi
سال: 1968
ISSN: 1882-4110,0021-4930
DOI: 10.3412/jsb.23.155